Gum Disease May Cause Alzheimer’s

You bastards better keep flossing! According to NewScientist

If you bled when you brushed your teeth this morning, you might want to get that seen to. We may finally have found the long-elusive cause of Alzheimer’s disease: Porphyromonas gingivalis, the key bacteria in chronic gum disease.

That’s bad, as gum disease affects around a third of all people. But the good news is that a drug that blocks the main toxins of P. gingivalis is entering major clinical trials this year, and research published today shows it might stop and even reverse Alzheimer’s. There could even be a vaccine.

Multiple research teams have been investigating P. gingivalis, and have so far found that it invades and inflames brain regions affected by Alzheimer’s; that gum infections can worsen symptoms in mice genetically engineered to have Alzheimer’s; and that it can cause Alzheimer’s-like brain inflammation, neural damage, and amyloid plaques in healthy mice.

“When science converges from multiple independent laboratories like this, it is very compelling,” says Casey Lynch of Cortexyme, a pharmaceutical firm in San Francisco, California.

In the new study, Cortexyme have now reported finding the toxic enzymes – called gingipains – that P. gingivalis uses to feed on human tissue in 96 per cent of the 54 Alzheimer’s brain samples they looked at, and found the bacteria themselves in all three Alzheimer’s brains whose DNA they examined.

Full article here.

I’m From Hollywood, I Have the Brains

Andy Kaufman began wrestling women as part of his stand-up act and then decided he wanted to get involved in professional wrestling. By the way, I remember seeing the above video clip on our local Saturday morning wrasslin’ program after spending the night at a friend’s house. Hilarious now, but as kids, we didn’t think the taunts were so funny.

Y’all probably know all this already, but here’s wiki-wiki-Wikipedia to tell the whole story about Kaufman’s feud with Jerry Lawler …

Kaufman initially approached the head of the World Wrestling Federation, Vince McMahon Sr., about bringing his act to the New York wrestling territory. McMahon dismissed Kaufman’s idea as the elder McMahon was not about to bring “show business” into his Pro Wrestling society. Kaufman had by then developed a friendship with wrestling reporter/photographer Bill Apter. After many discussions about Kaufman’s desire to be in the pro wrestling business, Apter called Memphis wrestling icon Jerry “The King” Lawler and introduced him to Kaufman by telephone.

Kaufman finally stepped into the ring (in the Memphis wrestling circuit) with a man—Lawler himself. Kaufman taunted the residents of Memphis by playing “videos showing residents how to use soap” and proclaiming the city to be “the nation’s redneck capital”. The ongoing Lawler-Kaufman feud, which often featured Jimmy Hart and other heels in Kaufman’s corner, included a number of staged “works”, such as a broken neck for Kaufman as a result of Lawler’s piledriver and a famous on-air fight on a 1982 episode of Late Night with David Letterman.

For some time after that first match, Kaufman appeared wearing a neck brace, insisting that his injuries were much worse than they really were. Kaufman would continue to defend the Inter-Gender Championship in the Mid-South Coliseum and offered an extra prize, other than the $1,000: that if he were pinned, the woman who pinned him would get to marry him and that Kaufman would also shave his head.

Eventually it was revealed that the feud and wrestling matches were staged works, and that Kaufman and Lawler were friends. This was not disclosed until more than 10 years after Kaufman’s death, when the Emmy-nominated documentary A Comedy Salute to Andy Kaufman aired on NBC in 1995. Jim Carrey, who revealed the secret, later went on to play Kaufman in the 1999 film Man on the Moon. In a 1997 interview with the Memphis Flyer, Lawler said he had improvised during their first match and the Letterman incident.

Although officials at St. Francis Hospital stated that Kaufman’s neck injuries were real, in his 2002 biography It’s Good to Be the King … Sometimes, Lawler detailed how they came up with the angle and kept it quiet. Even though Kaufman’s injury was legitimate, the pair exaggerated it. He also said that Kaufman’s furious tirade and performance on Letterman was Kaufman’s own idea, including when Lawler slapped Kaufman out of his chair. Promoter Jerry Jarrett later recalled that for two years, he would mail Kaufman payments comparable to what other main-event wrestlers were getting at the time, but Kaufman never deposited the checks.

Happy Halloween

If you’re in need of a last minute Halloween costume, here’s some great ideas. Please note the descriptions of each…

I’m going as The Better Future Bernie Sanders…

This Looks Kinda Cool …

Directed by Cary Fukunaga (Beasts of No Nation, True Detective). Available for viewing on Netflix September 21.

Set in a world somewhat like our world, in a time quite similar to our time, Maniac tells the stories of Annie Landsberg (Emma Stone) and Owen Milgrim (Jonah Hill), two strangers drawn to the late stages of a mysterious pharmaceutical trial, each for their own reasons. Annie’s disaffected and aimless, fixated on broken relationships with her mother and her sister; Owen, the fifth son of wealthy New York industrialists, has struggled his whole life with a disputed diagnosis of schizophrenia. Neither of their lives have turned out quite right, and the promise of a new, radical kind of pharmaceutical treatment—a sequence of pills its inventor, Dr. James K. Mantleray (Justin Theroux), claims can repair anything about the mind, be it mental illness or heartbreak—draws them and ten other strangers to the facilities of Neberdine Pharmaceutical and Biotech for a three-day drug trial that will, they’re assured, with no complications or side-effects whatsoever, solve all of their problems, permanently. Things do not go as planned.